Researchers have shown the endoplasmic reticulum (ER) stress pathway known as the unfolded protein response (UPR) is involved in the degradation of HLA-B27 heavy chain dimers. HLA-B27 is associated ...

The HLA-B27 genetic marker is known to be associated with increased risk for various arthropathies, including JIA. Whether the genetic marker's presence has prognostic value has been uncertain. In ...

Axial disease is common and burdensome in patients with psoriatic arthritis (PsA). Human leukocyte antigen-B27 (HLA-B27) is a risk factor for axial PsA; treatment response by HLA-B27 status is ...

HLA-B27 is strongly associated with spondyloarthritis (SpA) and has been suggested to promote this disease through the aberrant initiation of immune responses. Now, Robert Colbert and colleagues have ...

Prolonged, uncontrolled, anterior uveitis is a risk factor for spill-over inflammation to the posterior segment of the eye and subsequent cystoid macular edema. Persistent macular edema is the main ...

The etiopathogenesis of ankylosing spondylitis (AS) is not fully understood. However, there is strong evidence indicating that genetic factors play a pivotal role in disease susceptibility, and that ...

Human leukocyte antigen (HLA) typing is important in organ transplantation protocols, as they determine the likelihood of rejection. The HLA system is little understood, however. In simple terms, the ...

Second-line (2L) pembrolizumab (pembro) in Chinese patients (pts) with advanced melanoma: Three-year follow up (FU) of the phase 1 KEYNOTE-151 study. This is an ASCO Meeting Abstract from the 2021 ...

HLA-Arena can be integrated in computational pipelines to support basic cancer research or to help inform physicians in preclinical settings. It can be used to perform structure-based selection of ...

Background: A 36-year-old male presented with bilateral, anterior, chronic uveitis, with cystoid macular edema. Decimal visual acuity was 0.25 in the right eye and 0.20 in the left eye. Ankylosing ...