During the early window of Sunday's wild-card action, the Buffalo Bills defended their home turf at Highmark Stadium and sent the Denver Broncos packing with a 31–7 victory. Bo Nix and the Broncos got on the board early, taking a 7–0 lead before surrendering 31 straight points to the Josh Allen-led Bills offense.

With the end of Week 18, the regular NFL Season has come to an end with the playoffs right around the corner, setting up the path towards Super Bowl 59. A dominant victory over the Vikings saw the Lions clinch the NFC North title and acquire top seed.